Instrumentation

Methods Development

Instrumentation

Physics research efforts were largely focused on the development of 3D PET imaging instrumentation during the tenure of Dr. Townsend who was senior physicist, 1992-2003. Dr. Townsend’s collaborations with CTI PET systems led to the development of a combined PET/CT scanner which is applied to oncology imaging. Additional research included the development of a system to correct for head motion during PET scanning. Current efforts include optimization of PET/CT scanning conducted by Dr. Laymon, who joined the Department of Radiology in 2002.

Publications

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Methods Development

Methodology research has focused on neuroscience imaging, including the evaluation of PET radiotracers for the serotonin system. Novel statistical methods have been explored to extract temporal and spatial information from sequential PET data sets. Validation studies were performed to verify quantification of dopamine-D2 receptor binding in striatal sub-regions, to study d-amphetamine induced alterations in cerebral blood flow, and to evaluate MR-based methods for partial volume correction of functional brain image data. Research also included methodology development and validation for [¹⁸F]FDG PET imaging of the brain during sleep (Nofzinger 2000, 2002) and skeletal muscle function.

Publications

Radiotracer Evaluation

Price JC, Lopresti BJ, Mason NS, Holt DP, Meltzer CC, Smith GS, Gunn RN, Huang Y, Mathis CA. Analyses of [¹⁸F]altanserin bolus injection PET data II: Consideration of radiolabeled metabolites in humans. Synapse 2001; 41:11-21.

Price JC, Lopresti BJ, Mason NS, Holt DP, Huang Y, Mathis CA. Analyses of [¹⁸F]altanserin bolus injection PET data I: Consideration of radiolabeled metabolites in baboons. Synapse 2001; 41:1-10.

Lopresti BJ, Mathis CA, Price JC, Villemagne VL, Meltzer CC, Holt DP, Smith GS, Moore RY. Serotonin transporter binding in vivo: Further examination of [¹¹C]McN5652.In: Molecular and Pharmacological Brain Imaging with Positron Emission Tomography, (Gjedde et al., eds), Academic Press, San Diego, 2001, pp. 265-271.

Smith GS, Price JC, Lopresti BJ, Huang Y, Simpson N, Holt D, Mason NS, Meltzer CC, Sweet RA, Nichols T, Sashin D, Mathis CA. Test-retest variability of serotonin 5-HT2A receptor binding measured with positron emission tomography (PET) and [¹⁸F]altanserin in the human brain. Synapse 1998;30:380-392.

Methods Development/Validation

Xu L, Price JC, Mazumdar S. Temporal-spatial pattern extraction in PET data using partial least squares. Joint Statistical Meetings, New York, NY, 2002 (Abstract)

Greer PJ, Villemagne VL, Ruszkiewicz JA, Graves AK, Meltzer CC, Mathis CA, Price JC. MR Atlas of the baboon brain for functional neuroimaging studies. Brain Res Bull 2002; 58(4): 429-438

Price JC, Drevets WC, Ruszkiewicz J, Greer PJ, Villemagne VL, Xu, L, Cantwell MN, Mathis CA. Sequential [¹⁵O]water PET studies in baboons: Pre- and post-Amphetamine. J Nucl Med 2002;43(8):1090-1100.

Price JC, Xu L, Mazumdar S, Meltzer CC, Drevets WC, Mathis CA, Kelley DE, Ryan CM, Reynolds CF. Impact of Graphical Analysis Bias on Group Comparisons of Regional [carbonyl-11C]WAY Binding Potential Measures. Neuroimage 2002; 16(3):S72. (Abstract)

Drevets WC, Price JC, Kupfer DJ, Kinahan PE, Lopresti B, Mathis C. PET measures of amphetamine-induced dopamine release in ventral versus dorsal striatum. Neuropsychopharmacology 1999;21:694-709.

Meltzer CC, Cantwell MN, Greer P, Ben-Eliezer D, Smith GS, Frank G, Kaye W, Houck PR, Price JC. Does cerebral blood flow decline in healthy aging? A PET study with partial volume correction. J Nucl Med 2000;48(11):1842-1848

Meltzer CC, Kinahan PE, Greer PJ, Nichols TE, Comtat C, Cantwell MN, Price JC. Comparative evaluation of MR-based partial volume correction schemes for PET. J Nucl Med 1999;40:2053-2065.

Kelley DE, Williams KV, Price JC, Goodpaster B. Determination of the lumped constant for [¹⁸]Fluorodeoxyglucose in human skeletal muscle. J Nucl Med 1999;40(11):1798-1804.

Isoardi RA. Townsend DW. Carter CS. Herbster A. Dachille MA. Meltzer CC. A study of injected dose for brain mapping on the ECAT HR+: activation maps for a parametric verbal working memory task. Neuroimage. 9(1):145-53, 1999.

Nofzinger EA, Mintun MA, Price JC, Meltzer CC, Townsend D, Buysse DJ, Reynolds CF, Dachille M, Matzzie J, Kupfer DJ, Moore RY. A method for the assessment of the functional neuroanatomy of human sleep using FDG PET. Brain Res Protocols 1998;2(3):191-198.

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