Endocrinology

Oncology

Neuroscience

Endocrinology

Over several years, studies of skeletal muscle have been conducted to better understand insulin resistance and Type 2 diabetes.

Publications

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Oncology

Publications

Meltzer CC, Luketich JD, Friedman D, Charron M, Strollo D, Meehan M, Urso GK, Dachille MA, Townsend DW. Whole-body FDG PET for staging esophageal cancer: comparison with CT. Clinical Nuclear Medicine 25(11):882-887, 2000.

Luketich JD, Friedman DM, Wiegel TL, Nguyen NT, Meehan M, Keenan RJ, Townsend DW, Meltzer CC. Evaluation of distant metastases in esophageal cancer: 100 consecutive PET scans. Annals of Thoracic Surgery 1999;68:1133-1137.

Joe B, Fukui MB, Meltzer CC, Huang Q, Day RS, Greer PJ, Bozik ME. Comparison of manual and semi-automated methods for measuring brain tumor volumes. Radiology 212:811-16, 1999.

Peterson AM, Meltzer CC, Evanson EJ, Konziolka DS. The MR imaging response of brain metastases after gamma knife stereotactic radiosurgery. Radiology 211:807-14, 1999.

Luketich JD, Schauer PR, Meltzer CC, Belani C, Landreneau RJ, Urso GK, Townsend DW, Keenan RJ. The role of positron emission tomography in staging esophageal cancer. Annals Thoracic Surgery 64:765-69, 1997.

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Neuroscience

Examples of current research projects. Click here for a listing of relevant publications.

Mood, Sleep, Aging

• Neuroimaging Markers of Vulnerability to Depression
• Elucidating the Neurobiology of Post-partum Depression
• Functional Status of 5HT in Aging & Late-life Depression
• Geriatric Depression: Neurobiology of Treatment
• Sleep Guided Pet Studies in Depression
• Aging Well, Sleeping Efficiently: Intervention Studies
• Psychobiology and Treatment Response in Primary Insomnia
• Psychobiology of Suicidal Behavior in Borderline Personality Disorder

Eating Disorders

• Neurobiology of Feeding and Other Behaviors in Bulimia
• Serotonin-1A Trait Disturbance in Anorexia Nervosa

Medical

• Neuroimaging Medical Illness in Elderly Depression
• Cognitive and Cerebrovascular Sequelae of Hypertension
• Multi-tracer PET Quantitation of Insulin Action
  

Neurological

• Therapeutic correlates of Acetylcholinesterase PET imaging in Parkinson’s disease
• Monocytes in HIV Encephalitis
  

Publications

Mood

Drevets WC, Gautier C, Price JC, Kupfer DJ, Kinahan PE, Grace AA, Price JL, Mathis CA. Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria. Biol Psychiatry 2001; 49:81-96.

Nofzinger EA, Berman S, Fasiczka A, Miewald JM, Meltzer CC, Price JC, Sembrat RC, Wood A, Thase ME. Effects of bupropion SR on anterior paralimbic function during waking and REM sleep in depression: preliminary findings using [¹⁸F]-FDG PET. Psychiatry Research 2001; 106(2):95-111.

Drevets WC, Frank E, Price JC, Kupfer DJ, Holt D, Greer PJ, Huang Y, Gautier C, Mathis C. PET imaging of serotonin 1A receptor binding in depression. Biol Psychiatry 46:1375-1387, 1999.

Soloff PH, Meltzer CC, Greer PJ, Constantine D, Kelly TM. Fenfluramine-activated FDG-PET study of borderline personality disorder. Biological Psychiatry 47:540-547, 2000.

Nofzinger EA, Price J, Meltzer CC, Buysse DJ, Villemagne VL, Miewald JM, Sembrat RC, Steppe DA, Kupfer DJ. Towards a neurobiology of dysfunctional arousal in depression: NREM sleep [¹⁸F]-FDG-PET/spectral EEG sleep studies. Psychiatry Research: Neuroimaging 2000;98:71-91.

Nofzinger EA, Nichols TE, Meltzer CC, Price JC, Steppe DA, Miewald JM, Kupfer DJ, Moore RY. Changes in forebrain function from waking to REM sleep in depression: preliminary analyses of [¹⁸F]FDG PET studies. Psychiatry Res 1999;91(2):59-78.

Aging and Gender

Meltzer CC, Drevets WC, Price JC, Mathis CA, Lopresti B, Greer PJ, Villemagne V, Holt D, Mason NS, Houck PR, Reynolds CF, DeKosky ST, Gender-specific aging effects on the serotonin 1A receptor. Brain Research 895(1-2):9-17, 2001

Meltzer CC, Cantwell MN, Greer P, Ben-Eliezer D, Smith GS, Frank G, Kaye W, Houck PR, Price JC. Does cerebral blood flow decline in healthy aging? A PET study with partial volume correction. J Nucl Med 48(11):1842-1848, 2000.

Meltzer CC, Price JC, Mathis CA, Greer PJ, Cantwell MN, Houck PR, Mulsant B, Ben-Eliezer D, Lopresti B, DeKosky ST, Reynolds CF. PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders. American Journal of Psychiatry 156:1871-8, 1999.

Meltzer CC, Smith G, DeKosky ST, Mathis CA, Pollock BG, Moore RY, Kupfer DJ, Reynolds CF. Serotonin in aging, late life depression, and Alzheimer's disease: The emerging role of functional imaging. Neuropsychopharmacology 18(6):407-30, 1998

Meltzer CC, Smith G, Reynolds CF, Price JC, Mathis CA, Greer PJ, Lopresti B, Mintun MA, Pollock B, DeKosky ST. Reduced binding of [¹⁸F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction. Brain Research 813:167-71, 1998.

Diabetes, Eating Disorders, and Hypertension

Price JC, Kelley DE, Ryan CM, Meltzer CC, Drevets WC, Mathis CA, Mazumdar S, Reynolds CF, III. E-vidence of Increased Serotonin-1A Receptor Binding in Type 2 Diabetes: A Positron Emission Tomography Study. Brain Res 927(1):97-103, 2002.

Kaye WH, Frank G, Meltzer CC, Price JC, McConaha C, Crossan P, Klump K, Devlin B. Altered serotonin 2A receptor activity in women who have recovered from bulimia nervosa. Am J Psychiatry 158:1152-1155, 2001.

Frank GK, Kaye WH, Greer PJ, Meltzer CC, Price JC. Regional cerebral blood flow after recovery from bulimia nervosa. Psychiatry Research Neuroimaging Section 100:31-39, 2000.

Jennings JR. Muldoon MF. Ryan CM. Mintun MA. Meltzer CC. Townsend DW. Sutton-Tyrrell K. Shapiro AP. Manuck SB. Cerebral blood flow in hypertensive patients: an initial report of reduced and compensatory blood flow responses during performance of two cognitive tasks. Hypertension. 31(6):1216-22, 1998.

Neurology

Bohnen N, Kaufer D, Ivanco LS, Lopresti BJ, Koeppe RA, Davis JG, Mathis CA, Moore RY, DeKosky ST. Cortical Cholinergic function is more severely affected in Parkinsonian dementia than in Alzheimer’s disease: an in vivo PET study. Annals of Neurology, in press.

Kondziolka D, Wechsler L, Goldstein S, Meltzer C, Thulborn K, Gebel J, Janetta P, DeCesare S, Elder E, McGrogan M, Rietman MA, Bynum L. Transplantation of cultured human neuronal cells for patients with stroke. Neurology 55:565-569, 2000.

Venneti S, Lopresti BJ, Wang G, Bissel S, Mathis CA, Capuano S, Ruszkiewicz J, Reynolds I, Murphey-Corb M, Trichel A, Wisniewski S, Wiley CA. PET imaging of neurological disease in a macaque model of AIDS. Proc Nat Acad Sciences, in review.

Abstracts:
Mathis CA, Lopresti BJ, Davis JG, Ruszkiewicz J, Capuano SV, Murphey-Corb M, Myers R, Wiley CA. PET visualization of peripheral benzodiazepine receptor expression using [C-11]-PK11195 in macaque monkeys with SIV. J Nucl Med 42 (5): 905 Suppl., 2001.

Wiley CA, Bissel S, Wang G, Capuano S, Murphey-Corb M, Piatek M, Lifson JD, Lopresti B, Mathis CA. Positron emission tomography (PET) imaging of macrophage activation in SIV encephalitis. J Neuropathology Exp. Neurology 60 (5): 34, 2001

Bohnen NI, Kaufer DI, Ivanco LS, Hendrickson R, Lopresti B, Davis JG, Mathis CA, Meltzer CC, Moore RY, DeKosky ST. Relationship between acetylcholinesterase PET imaging and clinical response to donepezil treatment in Alzheimer’s disease. J Nucl Med 44(5) Suppl., 2003.

Bohnen NI, Kaufer DI, Ivanco LS, Hendrickson R, Lopresti B, Davis JG, Mathis CA, Meltzer CC, Moore RY, DeKosky ST. Cognitive-behavioral correlates of hemispheric cholinergic denervation in Parkinson’s disease without dementia. J Nucl Med 44(5) Suppl., 2003.

Bohnen NI, Kaufer DI, Lopresti B, Davis JG, Mathis CA, Dekosky ST, Moore Y. Cerebral acetylcholinesterase (AChE) activity in patients with dementia with Lewy bodies (DLB) and Parkinson’s disease with dementia (PDD). J Nucl Med 44(5) Suppl., 2003.

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