Radiochemist

N. Scott Mason, Ph.D., Research Assistant Professor. Scott has continued research interests in the development and application of radiosynthetic methods in the development of PET radioligands for the dopamine receptor system. Recent efforts have included the development of radioligands for use in PET oncology applications, as well as the application of PET in the area of developmental biology.


Education
King College,
Bristol TN		 B.S. 1984 Chemistry
Vanderbilt University,
Nashville TN		 Ph.D. 1991 Organic Chemistry

Selected Publications
  • Mason NS, Hewlett WA, Ebert MH, Schmidt DE, dePaulis T: Labeling of (S)-Des-4-Amino-3-[125I]Iodozacopride, a High-Affinity Radioligand for the 5-HT-3 Receptor. J. Label. Comp. Radiopharm. 1996;38:955-961.

  • Hewlett WA, dePaulis T, Mason NS, Schmidt DE, Trivedi BL, Zhang ZJ, Ebert MH : Synthesis and Radiolabeling of (S)-4-Amino-5-iodo-2-methoxy-N-(1-azabicyclo[2.2.2] oct-3-yl)benzamide, the Active Enantiomer of [125I]Iodozacopride, and Re-evaluation of its 5-HT3 Receptor Affinity. Chem. Pharm. Bull. 1997;45:2079-2084.

  • Kessler RM, Mason NS, Jones C, Price RC, Manning RG, Ansari MS, Rieck RW, Shelton R. "In Vivo Quantitation of Striatal and Extrastriatal Dopamine D2 Receptors in Human Brain Using PET and [18F]N-Allyl-5-fluoropropylepidepride" J. Nucl. Med. 97:289,1997.

  • Mason NS, Huang Y, Holt DP, Perevuznik JJ, Lopresti BJ, Mathis CA "Synthesis of Two Radiolabeled Metabolites of [18F]Altanserin: [18F]3-[2-[4-(4-Fluorophenylmethanol)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4-(1H)-quinazolinone and [18F] 4-(4-Fluorobenzoyl)piperidine" Radiopharmaceutical Chemistry Meeting 1997 Uppsalla.

  • Mason NS, Huang Y, Holt DP, Perevuznik JJ, Lopresti BJ, Mathis CA "Synthesis and Characterization of [18F]4-(4-Fluorobenzoyl)piperidine, an [18F]Altanserin Metabolite" J. Nucl. Med. 97:56,1997.

  • Hewlett WA, Schmidt DE, Mason NS, Trivedi BL, Ebert MH, dePaulis T : Synthesis and 5-HT-3 Receptor Binding of 2- and 3-(Halo)alkoxy Substituted (S)-N-(1-Azabicyclo[2.2.2] oct-3-yl)-5chlorobenzamides as Potential Radioligands. Nucl.Med.Biol. 1998;25:141-153.

  • Mathis CA, Mason NS, Holt DP, Lopresti BJ. "A Sensitive, Rapid Method to Quantitate Metabolites of (+) and (-)-[C-11]McN5652" J.Nucl. Med. 98:239,1998.

  • Huang Y, Mahmood K, Simpson NR, Mason NS, Mathis CA: Stereoconservative Synthesis of the Enantiomerically Pure Precursors of [11C](+)-McN 5652 and [11C](-)-McN 5652. J. Label. Comp. Radiopharm. 1998;41:9-17.

  • Holt DP, Mason NS, Mathis CA "Trapping and Incorporation of High Specific Activity [C-11]Carbon Dioxide. CTI User Meeting, San Francisco, April 1998

  • Price J, Mason N, Lopresti B, Holt D, Simpson N, Drevets W, Smith G, Mathis C, "PET measurements of endogenous neurotransmitter activity using high and low affinity radiotracers." In: Quantitative Brain Imaging with Positron Emission Tomography R. Carson et al. (eds.), Academic Press,1998, pp 441-448.

  • Lopresti B, Holt D, Mason, N, Huang Y, Ruszkiewicz J, Perevuznik J, Price J, Smith G, Mathis C, "Characterization of the radiolabeled metabolites of [18F]-altanserin: implications for kinetic modeling." In: Quantitative Brain Imaging with Positron Emission Tomography R. Carson et al. (eds.), Academic Press,1998, pp 293-298.

  • Meltzer CC, Drevets WC, Price JC, Lopresti B, Greer PJ, Villemagne V, Holt D, Mason NS,Houck PR, DeKoskly ST, Reynolds CF, Mathis CA. Gender-specific aging effects on the serotonin 1A receptor. Brain Res. 2001 Mar 23;895(1-2);9-17.

  • Price JC, Lopresti BJ, Mason NS, Holt DP, Huang Y, Mathis CA. Analyses of [18F]Altanserin Bolus Injection PET Data I: Consideration of Radiolabeled Metabolites in Baboons. Synapse. 2001 Jul;41(1):11-21. Synapse. 2001 Jul;41(1):1-10.

  • Price JC, Lopresti BJ, Meltzer CC, Smith GS, Mason NS, Huang Y, Holt DP, Gunn RN, Mathis CA. Analyses of [18F]Altanserin Bolus Injection PET Data II: Consideration of Radiolabeled Metabolites in Humans. 2001 Jul;41(1):11-21.

  • Mason NS, Mathis CA.Ê Radiohalogens for Positron Emission Tomography Imaging in "Positron Emission Tomography Basic Science and Clinical Practice."Ê Valk PE, Bailey DL, Townsend DW, Marsey MN (eds), Springer-Verlag (London), 2003.

  • Mason NS, Mathis CA. Positron Emission Tomography Radiochemistry. Neuroimag Clin N Am, 13:671-687, 2003.

Ways to reach Dr. Mason

U.S. Postal Mail
N. Scott Mason, Ph.D.
University of Pittsburgh Medical Center
PUH PET Facility, B-938
200 Lothrop Street
Pittsburgh, PA 15213-2582
U.S.A.

Tel. (412) 647-0719
Fax (412) 647-0700

Or

Send email to Dr. Mason at masonns@upmc.edu

radiologypethelpdesk@msx.upmc.edu Updated: 7/18/03