Physicist

Julie C. Price, Ph.D., Associate Professor of Radiology, Head of PET Methodology. Julie's primary research interests are in integrated approaches to the analyses of multiple intra-subject neuroimaging measures (e.g. blood flow, neuroreceptor binding) in studies of medical illness, neuropsychiatric disorders, and aging.


Education
University of Wisconsin,
Madison, WI		 B.S. 1982 Physics
University of Wisconsin,
Madison, WI		 M.S. 1985 Medical Physics
Johns Hopkins University,
Baltimore, MD		 Ph.D. 1992 Radiological Health Sciences
NIH PET Department,
Bethesda, MD		 Post-doc 1992-94 Quantitative PET

Selected Publications
  • Price JC, Mayberg HS, Dannals RF, Wilson AA, Ravert HT, Sadzot B, Rattner Z, Kimball A, Feldman MA, Frost JJ. Measurement of benzodiazepine receptor number and affinity in humans using tracer kinetic modeling, positron emission tomography, and [11C]flumazenil. J Cereb Blood Flow Metab 1993;13:656-667.

  • Price JC, Bacharach SL, Freedman N, Carson RE. Noise reduction in PET attenuation correction by maximum likelihood (ML) histogram sharpening of attenuation images. J Nucl Med 1996;37(5):786-794.

  • Drevets WC, Price JC, Kupfer DJ, Kinahan PE, Lopresti B, Mathis C. PET measures of amphetamine-induced dopamine release in ventral versus dorsal striatum. Neuropsychopharmacology 1999;21:694-709.

  • Price JC, Lopresti BJ, Mason NS, Holt DP, Huang Y, Mathis CA. Analyses of [18F]altanserin bolus injection PET data I: Consideration of radiolabeled metabolites in baboons. Synapse 2001; 41:1-10.

  • Price JC, Lopresti BJ, Mason NS, Holt DP, Meltzer CC, Smith GS, Gunn RN, Huang Y, Mathis CA. Analyses of [18F]altanserin bolus injection PET data II: Consideration of radiolabeled metabolites in humans. Synapse 2001; 41:11-21.

  • Price JC, Kelley DE, Ryan CM, Meltzer CC, Drevets WC, Mathis CA, Mazumdar S, Reynolds CF, III. Evidence of Increased Serotonin-1A Receptor Binding in Type 2 Diabetes: A Positron Emission Tomography Study. Brain Res 2002; 927(1): 97-103.

  • Price JC, Drevets WC, Ruszkiewicz J, Greer PJ, Villemagne VL, Xu, L, Cantwell MN, Mathis CA. Sequential [15O]water PET studies in baboons: Pre- and post-Amphetamine. J Nucl Med 2002;43(8):1090-1100.

  • Williams KV, Bertoldo A, Mattioni B, Price JC, Cobelli C, Kelley DE. Glucose transport and phosphorylation in skeletal muscle in obesity: Insight from a muscle specific PET model. J Clin Endo & Metab 2003; 88(3):1271-127

  • Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergström M, Savitcheva I, Huang G, Estrada S, Ausén B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Långström B. Imaging brain amyloid in Alzheimer’s disease using the novel PET tracer, PIB. Ann Neurol 2004; 55:306-319

  • Bailer UF, Price JC, Meltzer CC, Mathis CA, Frank GK, Weissfeld L, McConaha CW, Henry SE, Brooks-Achenbach S, Barbarich NC, Kaye WH. Altered 5-HT2A receptor binding density after recovery from bulimia-type anorexia nervosa: Relationships to harm avoidance and drive for thinness. Neuropsychopharmacology 2004; 29: 1143-1155.

  • Meltzer CC, Price JC, Mathis CA, Butters MA, Ziolko SK, Moses-Kolko E, Mazumdar S, Mulsant BH, Houck PR, Lopresti BJ, Weissfeld LA, Reynolds CF. Serotonin 1A receptor binding and treatment response in late-life depression. Neuropsychopharmacology 2004 29(12):2258-2265.

  • Nofzinger EA, Buysse DJ, Germain A, Price JC, Meltzer CC, Miewald JM, Kupfer DJ. Alterations in regional cerebral glucose metabolism across waking and non-rapid eye movement sleep in depression. Arch Gen Psychiatry 2005 62(4):387-96

  • Bertoldo A, Price JC, Mathis CA, Mason NS, Holt DP, Kelley C, Cobelli C, Kelley DE. Quantitative assessment of glucose transport in skeletal muscle: Dynamic PET imaging of [O-methyl-11C]3-O-methyl-D-glucose. J Clin Endo & Metab 2005 90(3): 1752-9.

  • Jennings RJ, Muldoon MF, Ryan CM, Price JC, Greer PJ, Sutton-Tyrrell K, van der Veen F, Gamalo M, and Meltzer CC. Reduced Cerebral Blood Flow Response and Compensation among Untreated Hypertensives. Neurology 2005 64:1358-1365

  • Mathis CA, Klunk WE, Price JC, DeKosky ST. Imaging Technology for Neurodegenerative Diseases: Progress toward detection of specific pathologies. Arch Neurol 2005 62:196-200

  • Price JC, Klunk WE, Lopresti BJ, Lu X, Hoge JA, Ziolko SK, Holt DP, Meltzer CC, DeKosky ST, Mathis CA. Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B. J Cereb Blood Flow Metab 2005 doi:10.1038/sj.jcbfm.9600146

Ways to reach Dr. Price

U.S. Postal Mail
Julie Price, Ph.D.
University of Pittsburgh Medical Center
PUH PET Facility, B-938
200 Lothrop Street
Pittsburgh, PA 15213-2582
U.S.A.

Tel. (412) 647-0714
Fax (412) 647-0700

Or

Send email to Dr. Price at pricejc@upmc.edu

radiologypethelpdesk@upmc.edu Updated: 6/28/05