Radiochemist

Chester A. Mathis, Ph.D., Professor of Radiology, Director PET Facility. Chet has a long standing interest in applying synthetic radiochemistry techniques to develop PET radioligands for the serotonin and dopamine neuroreceptor systems. Recent efforts have also included the development of PET radiotracers to image and evaluate amyloid deposition in Alzheimer's disease.


Education
Humboldt State University,
Arcata, CA		 B.S. 1972 Chemistry
University of California,
Davis, CA		 Ph.D. 1979 Physical Chemistry
Crocker Nuclear Laboratory,
University of California,
Davis, CA		 Post-doc 1979-80 Radiochemistry
Donner Laboratory,
Lawrence Berkeley Laboratory,
University of California,
Berkeley, CA		 Post-doc 1980-82 Radiochemistry

Selected Recent Publications
  • Drevets WC, Frank E, Price JC, Kupfer DJ, Greer PJ, Mathis C. Serotonin Type-1A Receptor Imaging in Depression. Nuclear Medicine and Biology 27:499-507 (2000).
  • Klunk WE, Wang Y, Huang G-F, Debnath ML, Holt DP, Mathis CA. Uncharged Thioflavin-T Derivatives Bind to Amyloid-Beta Protein with High Affinity and Readily Enter the Brain. Life Sciences 69:1471-1484 (2001).
  • Link CD, Johnson CJ, Fonte V, Paupard M-C, Hall DH, Styren S, Mathis CA, Klunk WE. Visualization of Fibrillar Amyloid Deposits in Living, Transgenic Caenorhabditis elegans Animals Using the Sensitive Amyloid Dye, X-34. Neurobiology of Aging 22:217-226 (2001).
  • Drevets WC, Gautier C, Price JC, Kupfer DJ, Kinahan P, Grace A, Price JL, Mathis CA. Amphetamine-Induced Dopamine Release in Human Ventral Striatum Correlates with Euphoria. Biol Psych 49:81-96 (2001).
  • Mathis CA, Bacskai BJ, Kajdasz ST, McLellan ME, Frosch MP, Hyman BT, Holt DP, Wang Y, Huang G-F, Debnath ML, Klunk WE. A Lipophilic Thioflavin T Derivative for Positron Emission Tomography (PET) Imaging of Amyloid in Brain. Bioorganic and Medicinal Chemistry Letters 12:295-298 (2002).
  • Bacskai BJ, Klunk WE, Mathis CA, and Hyman BT. Imaging Amyloid-b Deposits In Vivo. J. Cerebral Blood Flow Metab., 22:1035-1041 (2002).
  • Klunk WE, Bacskai BJ, Mathis CA, Kajdasz ST, McLellan ME, Frosch MP, Debnath ML, Holt DP, Wang Y, and Hyman BT. Imaging Ab plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 61:797-805 (2002).
  • Wang Y, Klunk WE, Huang GF, Debnath ML, Holt DP, and Mathis CA. Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease. J. Mol. Neurosci. 19:11-16 (2002).
  • Klunk WE, Wang Y, Huang G-F, Debnath ML, Holt DP, Shao L, Hamilton RL, Ikonomovic M, DeKosky ST and Mathis CA. The binding of BTA-1 to post-mortem brain homogenates is dominated by amyloid component. J. Neuroscience 23:2086-2092 (2003).
  • Mathis CA, Wang Y, Holt DP, Huang G-F, Debnath ML, Klunk WE. Synthesis and Evaluation of 11C-Labeled 6-Substituted 2-Aryl Benzothiazoles as Amyloid Imaging Agents. J. Med. Chem. 46:2740-2755 (2003).
  • Bacskai BJ, Gregory A, Hickey GA, Skoch J, Stephen T, Kajdasz ST, Wang Y, Huang G-F, Mathis CA, Klunk WE, Hyman BT. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-b ligand in transgenic mice. PNAS 100:12462-12467 (2003).
  • Bohnen NI, Kaufer DI, Ivanco LS, Lopresti B, Koeppe RA, Davis JG, Mathis CA, Moore RY, DeKosky ST. Cortical Cholinergic Function Is More Severely Affected in Parkinsonian Dementia Than in Alzheimer Disease. Arch. Neurology 60:1745-1748 (2003).
  • Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergstrom M, Savitcheva I, Huang G-F, Estrada S, Ausen B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G, Mathis CA, Langstrom B. Imaging Brain Amyloid in Alzheimer’s Disease with Pittsburgh Compound-B. Annals of Neurology 55: 306-319 (2004).
  • Venneti S, Lopresti BJ, Wang G, Bissel SJ, Mathis CA, Meltzer CC, Boada F, Capuano III S, Kress J, Davis DK, Ruszkiewicz J, Reynolds IJ, Murphey-Corb M, Trichel AM, Wisniewski SR, Wiley CA. PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS. J. Clinical Invest. 113: 981-989 (2004).
  • Mathis CA, Wang Y, Klunk WE. Imaging b-Amyloid Plaques and Neurofibrillary Tangles in the Aging Human Brain. Current Pharmaceutical Design 10: 1469-1492 (2004).

Ways to reach Dr. Mathis

U.S. Postal Mail
Chester Mathis, Ph.D.
PET Facility, B-938
UPMC Presbyterian Hospital
200 Lothrop Street
Pittsburgh, PA 15213-2582
U.S.A.

Tel. (412) 647-0736
Fax (412) 647-0700

Or

Send email to Dr. Mathis at mathisca@upmc.edu

radiologypethelpdesk@msx.upmc.edu Updated: 2/15/06