Vice Chairman of Radiology Research

Carolyn Cidis Meltzer, M.D., Associate Professor of Radiology, Psychiatry, and Neurology, Chief of Neuroradiology, Vice Chairman of Radiology Research, and Acting Medical Director of the MR Research Center. Dr. Meltzer is a neuroradiologist and nuclear medicine physician with expertise as an investigator of brain structure-function relationships in aging and age-related neuropsychiatric disorders. Her research interests center on neuroreceptor and anatomical imaging studies of aging. These include PET studies of the serotonin neurotransmitter system in normal aging, late-life depression, and Alzheimer's disease, and the development of magnetic resonance imaging-based methods to correct PET images for partial volume effects due to cerebral atrophy. Other research interests include whole-body PET imaging applications in oncology, and brain PET and MR imaging of epilepsy.


Education
Cornell University,
Ithaca, NY		 B.S. 1983 Neurobiology
The Johns Hopkins University
School of Medicine		 M.D. 1987 Medicine

Selected Publications
  • Meltzer CC, Leal JP, Mayberg HS, Wagner HN, Frost JJ. Correction of PET data for partial volume effects in human cerebral cortex by magnetic resonance imaging. Journal of Computer Assisted Tomography 1990;14:561-70.
  • Meltzer CC, Frost JJ. Partial Volume Correction in Emission Computed Tomography: Focus on Alzheimer Disease, in: RW Thatcher, M Hallet, T Zeffiro, ER John, M Huerta, eds. Functional Neuroimaging. Academic Press, San Diego, 1994;163-170.
  • Meltzer CC, Zubieta JK, Links JM, Brakeman P, Stumpf MJ, Frost JJ. MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution. Journal of Cerebral Blood Flow and Metabolism 1996;16:650-658.
  • Meltzer CC, Zubieta JK, Brandt J, Tune LE, Mayberg HS, Frost JJ. Regional hypometabolism in Alzheimer disease as measured by PET following correction for effects of partial volume averaging. Neurology 1996;47:454-461.
  • Luketich JD, Schauer PR, Meltzer CC, Belani C, Landreneau RJ, Urso GK, Townsend DW, Keenan RJ. The role of positron emission tomography in staging esophageal cancer. Annals of Thoracic Surgery 1997;64:765-769.
  • Meltzer CC, Wells SW, Becher MW, Flanagan KM, Oyler GA, Lee RR. AIDS-related MR hyperintensity of the basal ganglia. American Journal of Neuroradiology 1998;19:83-89.
  • Nofzinger EA, Mintun MA, Price J, Meltzer CC, Townsend DW, Buysse DJ, Reynolds CF, Dachille M, Matzzie J, Kupfer DJ, Moore RY. A method for the assessment of the functional neuroanatomy of human sleep using FDG PET. Brain Research Protocols 1998;2:191-198.
  • Meltzer CC, Smith G, DeKosky ST, Mathis CA, Pollock BG, Moore RY, Kupfer DJ, Reynolds CF. Serotonin in aging, late life depression, and Alzheimer's disease: The emerging role of functional imaging. Neuropsychopharmacology 1998;18(6):407-430.
  • Yonas H, Pindzola RR, Meltzer CC, Sasser H. Qualitative versus quantitative assessment of cerebrovascular reserves. Neurosurgery 1998;42:1005-1012.
  • Meltzer CC, Smith G, Price JC, Reynolds CF, Mathis CA, Greer PJ, Lopresti B, Mintun MA, Pollock B, Ben-Eliezer D, Cantwell MN, Kaye W, DeKosky ST. Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction. Brain Research 1998;813;167-171.
  • Meltzer CC, Price JC, Mathis CA, Greer PJ, Cantwell MN, Houck PR, Mulsant B, Ben-Eliezer D, Lopresti B, DeKosky ST, Reynolds CF. PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders. American Journal of Psychiatry 1999;156:1871-1878.
  • Meltzer CC. Neuropharmacology and Receptor Studies in the Elderly. In: A Kumar, ed. Neuroimaging in Late-Life Mental Disorders: Technology in Search of Neurobiology. Some perspectives as we approach the next century, Supplement to Journal of Geriatric Psychiatry and Neurology 1999;12(3):137-149.
  • Meltzer CC, Kinahan P, Nichols TE, Greer PJ, Comtat C, Cantwell MN, Lin MP, Price JC. Comparative evaluation of MR-based partial volume correction schemes for PET. Journal of Nuclear Medicine 1999;40:2053-2065.
  • Meltzer CC, Scheuer M, Adelson PD, Van Cott A, Crumrine P, Brenner R. Planned ictal FDG PET imaging for localization of epileptic foci. Epilepsia 2000;41:193-200.
  • Soloff PH, Meltzer CC, Greer PJ, Constantine D, Kelly TM. Fenfluramine-activated FDG-PET study of borderline personality disorder. Biological Psychiatry 2000;47:540-547.
  • Meltzer CC, Cantwell MN, Greer P, Ben-Eliezer D, Smith GS, Frank G, Kaye W, Houck PR, Price JC. Does cerebral blood flow decline in healthy aging? A PET study with partial volume correction. Journal of Nuclear Medicine 2000;48(11):1842-1848.
  • Meltzer CC, Luketich JD, Friedman D, Charron M, Strollo D, Meehan M, Urso GK, Dachille MA, Townsend DW. Whole-body FDG PET for staging esophageal cancer: comparison with CT. Clinical Nuclear Medicine 2000;25(11):882-887.
  • Meltzer CC, Drevets WC, Price JC, Mathis CA, Lopresti B, Greer PJ, Villemagne V, Holt D, Mason NS, Houck PR, Reynolds CF, DeKosky ST, Gender-specific aging effects on the serotonin 1A receptor. Brain Research 2001;895(1-2):9-17.
  • Meltzer CC, Kondziolka D, Villemagne VL, Wechsler L, Goldstein S, Thulborn KR, Gebel J, Elder EM, DeCesare S, Jacobs A. Metabolic response to cerebral implantation of cultured human neuronal cells in patients with fixed motor deficit following cerebral infarction. Neurosurgery 2001;49:586-592.
  • Makhija S, Howden N, Edwards R, Kelley J, Townsend DW, Meltzer CC. PET/CT Imaging for the detection of recurrent ovarian and fallopian tube carcinoma: a retrospective review. Gynecologic Oncology 2002;85:53-58.
  • Bell-McGinty SB, Butters MA, Meltzer CC, Greer PJ, Reynolds CF, Becker JT. Brain morphometric abnormalities in late-life depression: long-term neurobiological effects of illness duration. American Journal of Psychiatry 2002;159:1424-1427.
  • Soloff PH, Meltzer CC, Becker C, Greer PJ, Kelly TM, Constantine D. Impulsivity, suicide and prefrontal hypometabolism in borderline personality. Psychiatry Research: Neuroimaging 2003;123:153-163.
  • Meltzer CC (Guest Editor). Neurological Applications of PET. Neuroimaging Clinics of North America, W.B. Saunders Co., Philadelphia, 2003;13(4).

Ways to reach Dr. Meltzer

U.S. Postal Mail
Carolyn Cidis Meltzer, M.D.
University of Pittsburgh Medical Center
CHP MT 3960
200 Lothrop Street
Pittsburgh, PA 15213-2582
U.S.A.

Tel. (412) 647-3553
Fax (412) 647-0738

Or

Send email to Dr. Meltzer at meltzercc@upmc.edu

radiologypethelpdesk@msx.upmc.edu Updated: 7/18/03